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Cisplatin hearing loss data

WebCisplatin-induced early-onset ototoxicity is linked to hearing loss. The mechanism by which cisplatin causes ototoxicity remains unclear. The purpose of this study was to … WebCisplatin is an effective chemotherapeutic agent against pediatric cancers; however, ototoxicity is a concern. This study describes the frequency, severity, and clinical course …

Cisplatin-Induced Ototoxicity: Updates on Molecular Targets

Web顺铂治疗导致的永久性听力损失率在 40% 到 80% 之间,并且与相当大的发病率和对生活质量的负面影响有关。 目前,没有 FDA 批准的预防顺铂引起的听力损失的疗法。 HMG-CoA 还原酶抑制剂(他汀类药物)由于假定的多效性作用、减少炎症和氧化应激而受到关注。 一些临床前和回顾性研究表明,同时服用他汀类药物可以减少顺铂相关的听力损失。 目的: … WebMay 19, 2016 · He is actively involved in several human clinical trials looking at the prevention of cisplatin ototoxicity that may drastically decrease … dyson hand vac reviews https://ods-sports.com

Prevalence and risk factors for cisplatin-induced hearing …

WebSep 21, 2016 · Individually, children in this series first showed decreases in hearing after cumulative cisplatin doses ranging between 75 and 600 mg/m 2 and carboplatin doses between 800 and 3,420 mg/m 2. Patients treated for germ cell tumors (Children's Oncology Group 8882) received the highest cumulative doses of cisplatin. WebJan 4, 2024 · BACKGROUNDCisplatin is widely used to treat adult and pediatric cancers. It is the most ototoxic drug in clinical use, resulting in permanent hearing loss in … WebLovastatin protects against cisplatin-induced hearing loss in mice. Cisplatin is used to treat a variety of solid tumors in both children and adults. However, cisplatin has serious … csdn win10激活

History of Changes for Study: NCT04915183

Category:Adenosine A1 Receptor Protects Against Cisplatin Ototoxicity by ...

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Cisplatin hearing loss data

Cisplatin and Hearing Loss: Until Now, an Unquantified Risk

WebFeb 12, 2024 · Overall, the study showed that 44% of pediatric patients treated with cisplatin suffered from moderate to severe hearing loss. But the data showed that not … WebJun 1, 2024 · Overall, for all cancers treated with cisplatin, the incidence of hearing loss is about 50%. But some specific cancers, especially children who have cancers in very early childhood—say, younger than 5 years old—tend to have a more severe cisplatin-induced hearing loss and at a higher incidence.

Cisplatin hearing loss data

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WebMar 29, 2024 · This hearing disorder results from temporary or permanent inner ear dysfunction, typically causing bilateral high-frequency sensorineural hearing loss that progresses to lower frequencies with continued exposure. 3 The risk of permanent bilateral sensorineural hearing loss and tinnitus can occur both during treatment and long-term … WebOct 6, 2024 · Cisplatin belongs to a group of platinum-based chemotherapy drugs. Research has suggested that hearing loss may result from damage caused by the …

WebAug 31, 2016 · Ototoxicity poses a major problem to the cancer patient, as the quality of life after receiving cisplatin chemotherapy may be negatively affected due to hearing loss, resulting in social, emotional, and vocational difficulties, as effective communication is … WebJan 26, 2024 · But cisplatin and other similar platinum-containing drugs can damage the cochlea, leaving 40%–80% of adults, and at least 50% of children, with significant …

WebThirteen percent sustained a significant hearing handicap. An interindividual variation was found, ranging from severe hearing loss after the first course to unaffected hearing after … Webcisplatin (Rx) Brand and Other Names: Classes: Antineoplastics, Alkylating; Antineoplastics, Platinum Analog Print Dosing & Uses AdultPediatricGeriatric Dosage Forms & Strengths injectable...

WebFeb 15, 2024 · Overall, the study showed that 44% of pediatric patients treated with cisplatin suffered from moderate to severe hearing loss. But the data showed that not …

WebFeb 24, 2024 · Cisplatin is one of the most effective chemotherapy agents, used in just under half of pediatric cancer cases. Permanent hearing loss is a common side effect of … csdn win10安装WebSigns and symptoms seen in children as ototoxicity develops include: High-frequency (≥4 kHz) sensorineural hearing loss that is bilateral (affecting both sides), progressive, and … dyson hand vacuum for mattressesWebCisplatin-induced hearing loss is mainly attributed to oxidative stress, but recent data suggest that inflammation could be the trigger event leading to inner ear cell death through endoplasmic reticulum (ER) stress, autophagy, necroptosis, and then intrinsic apoptosis. csdnwin10激活码WebJul 13, 2024 · Hearing loss can have significant long-term consequences for children treated for cancer, said Edward Neuwelt, M.D., of Oregon Health & Science University, who helped lead both recent trials. “Around 60% to … csdn win11 安卓子系统WebCisplatin is one of the most effective chemotherapy agents, used in just under half of pediatric cancer cases. Permanent hearing loss is a common side effect of this … csdn win7 isoWebFeb 1, 2024 · Tell you doctor right away if you have blood in urine, change in frequency of urination or amount of urine, difficulty in breathing, drowsiness, increased thirst, loss of appetite, nausea or vomiting, swelling of the feet or lower legs, or weakness. csdn win10激活码WebNov 21, 2024 · Cisplatin chemotherapy causes permanent hearing loss in 40–80% of treated patients. It is unclear whether the cochlea has unique sensitivity to cisplatin or is … csdn win10密钥