WebAmong these treatments, the fibroblast growth factor receptor (FGFR) 2 inhibitor pemigatinib has received accelerated approval in April 2024 by the US Food and Drug Administration (FDA) in CCA patients harboring FGFR2 gene fusions or other rearrangements, on the basis of the results of the FIGHT-202 trial, and thus, representing the first ... WebProgression-free survival (or PFS) was a secondary endpoint in the FIGHT-202 study. In FIGHT-202, the median PFS was 6.9 months. Overall survival (or OS) was also a secondary endpoint in FIGHT-202. Median OS was 21 months. Median follow-up at time of data cutoff was 15.4 months. The overall survival data were not mature at the data cutoff.
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WebDec 19, 2024 · The potent FGFR1-3 inhibitor pemigatinib (INCB054828) showed preliminary efficacy and safety signals in the phase II FIGHT-202 trial (NCT02924376) of patients with previously treated advanced,... WebOct 21, 2024 · The updated results from the Phase 2 FIGHT-202 trial evaluating pemigatinib, a selective fibroblast growth factor receptor (FGFR) inhibitor, as a treatment for patients with previously treated, locally advanced or metastatic cholangiocarcinoma presented at ESMO 2024 include the final result for the primary endpoint. In patients … hotel swarn towers bareilly
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WebApr 12, 2024 · Hollebecque A, Silverman I, Owens S, et al. Comprehensive genomic profiling and clinical outcomes in patients (pts) with fibroblast growth factor receptor … WebJul 23, 2024 · A detailed genetic analysis of the original data from the FIGHT-202 trial (NCT02924376) , including DNA-seq and RNA-seq data was conducted using the R software (v.4.0.2; R Core Team, 2016). WebApr 20, 2024 · Efficacy was investigated in FIGHT-202 (NCT02924376), a multicenter open-label single-arm trial, in 107 patients with locally advanced unresectable or metastatic … hotels warrnambool victoria