Hif and renin
WebNational Center for Biotechnology Information Web13 de jan. de 2024 · 10) Renal Artery Stenosis. Renal artery stenosis, or the narrowing of one or both of the arteries that carry blood to the kidneys, decreases kidney blood flow. …
Hif and renin
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Web5 de out. de 2024 · Insights into the role of the tumor suppressor pVHL in oxygen sensing motivated the testing of drugs that target the transcription factor HIF or HIF-responsive growth factors, such as VEGF, for ... Web9 de jun. de 2015 · HIF-2 is activated by hypoxic conditions and controls the production of erythropoietin by renal peritubular ... Renin-producing cells can be induced to synthesize …
WebInterestingly, HIFs respond to a multitude of changes during pregnancy, including 1) low oxygen, 2) renin-angiotensin system (RAS), 3) cytokines, and 4) growth factors, all of … Web23 de jun. de 2024 · The renin angiotensin aldosterone system (RAAS) plays a key function in renovascular hypertension induced by renal artery stenosis (RAS). RAS causes a decrease in renal perfusion in the stenosed kidney which in turn stimulates renin the rate limiting enzyme in RAAS. This stimulation triggers a series of events starting with renin …
Web20 de out. de 2024 · The hypobaric and hypoxic conditions of high-altitude areas exert adverse effects on the respiratory, circulatory and nervous systems. The kidneys have … WebHypoxia-inducible factor (HIF) is a sensor of hypoxia and a regulator of the cellular hypoxic response. HIF is a heterodimeric complex comprised of an α-subunit, usually HIF-1α, and a β-subunit, usually the aryl hydrocarbon receptor nuclear translocator (ARNT). Under normoxic conditions HIF-1α is polyubiquitylated and targeted for ...
WebNational Center for Biotechnology Information
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