Polyethylene glycol 400 toxicity
WebCremophor in Polyethylene Glycol 400 Vehicle Formulations in Sprague-Dawley Rats and Beagle Dogs Alan H. Stokes1, Daniel C. Kemp1, Brenda Faiola1,2, Holly L. Jordan1, ... WebNon-reproductive organ system toxicity ... ETHOXYLATED 1,2-ETHANEDIOL; POLYETHYLENE GLYCOL; POLYOXYETHYLENE ETHER, PEG-400, POLY(OXY-1,2 …
Polyethylene glycol 400 toxicity
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Web”Recognition, treatment, and prevention of propylene glycol toxicity.”Semin Dial.2007, May-Jun;20(3):217-9. Assessment report EMA/175205/2014 Page 4 . ... that contain PG daily doses in excess of 200 mg/kg if for used in children and 400 mg/kg if for used in adults. However, these thresholds that except otherwise stat ed, ... WebCommercial product name Polyethylene glycol 400, PEG 400. Use of the substance/preparation Petroleum chemicals, coatings, lubricants, plastics, inks, …
WebOct 16, 2024 · PEG-400 (polyethylene glycol 400), a low-molecular-weight grade of polyethylene glycol, is widely used in a variety of pharmaceutical formulations such as … WebJul 26, 2024 · Polyethylene glycol (PEG) is an inert, water soluble polymer, used for decades in pharmaceuticals. Although PEG is considered safe, concerns persist about the potential adverse effects of long-term exposure to PEG-containing therapies, specifically in children, following the introduction of PEGylated recombinant factor products used for the …
WebPOLYETHYLENE GLYCOL, 400 Revision date: 2024/10/14 Page: 6/9 Version: 5.0 (30239363/SDS_GEN_US/EN) Assessment other acute effects Assessment of STOT single: Based on the available information there is no specific target organ toxicity to be … WebApr 1, 2011 · Polyethylene glycol 400 (PEG-400) has been used in injections. However, limited data are available concerning the toxicity of a high dose of PEG-400 following …
WebPEG s (polyethylene glycols) are petroleum-based compounds that are widely used in cosmetics as thickeners, solvents, softeners, and moisture-carriers. PEG s are commonly used as cosmetic cream bases. They are also used in pharmaceuticals as laxatives. Health and Environmental Hazards. Depending on manufacturing processes, PEG s may be …
WebThe triethylene glycol (TEG) showed obvious cytotoxicity over 10 mg mL −1 ( p < 0.05; contrast with any other oligomer when concentration is over 5 mg mL −1) and the IC50 … ireland\u0027s capital cityWebJan 17, 2024 · Polyethylene glycol identified in this section may be safely used in food in accordance with the following prescribed conditions: (a) Identity. (1) The additive is an addition polymer of ethylene oxide and water with a mean molecular weight of 200 to 9,500. (2) It contains no more than 0.2 percent total by weight of ethylene and diethylene ... ireland\u0027s country codeWebPolyethylene glycol 400 (PEG400) is a commonly used co-solvent. ... in rats treated with 50 or 100 v/v% PEG400. 51 We had verified that oral 50% PEG400 at 20 mL kg −1 did not … ireland\u0027s celtic demons ghost adventuresWebFeb 1, 1995 · Vehicle toxicity and tolerability data are not readily available for a number of combination vehicles therefore, an i.v. tolerability studies was planned in rats with 5% v/v Pharmasolve (NMP), 45% v/v Propylene glycol (PG) and 50% v/v Polyethylene glycol (PEG) 400 combination, at dose volume of 0.5, 1, 2 and 5 mL/kg body weight for 28 days. ireland\u0027s diseaseWebThe surface charge of iron oxide nanoparticles (IONPs) plays a critical role in the interactions between nanoparticles and biological components, which significantly affects their toxicity in vitro and in vivo. In this study, we synthesized three differently charged IONPs (negative, neutral, and positive) based on catechol-derived dopamine, polyethylene … ireland\u0027s coat of armsWebEthylene glycol is a potent cause of acute toxicity in humans. In contrast, propylene glycol is a “generally recognized as safe” additive for foods and medications. Most reported cases … ireland\u0027s economic systemWebFeb 1, 1995 · Life Sciences 23, 2499-2502. Lockard J. S., Levy R~ H., Congdon W. C. and DuCharme L. L. (1979) EffL'acy and toxicity of the solvent polyethylene glycol 400 in monkey model. Epilepsia 20, 77-84. Ponzio N. M. (1980) Lymphocyte responses to syngeneic antigens. 1. Enhancement of the murine autologous mixed lymphocyte … ireland\u0027s current energy needs